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Statistical studies help physicians to see patterns and associations not always discernable up close, so certain things become clear, such as which individuals may be more at risk to experience complications from LCMN.
For example, of the 1003 individuals with congenital nevi in the registry, 76 — or 7.6 percent — also have been diagnosed with neurocutaneous melanocytosis (NCM).
For instance, while many parents added their child to the registry at birth or soon after, they have added little information in the meantime and many entries are incomplete.
Another problem is that variables noted are not clearly defined, or standardized, so the information provided is unclear.
In these patients, the risk of NCM was higher in those with a family history of congenital nevi, when they have many satellites and when their main nevus is located on the back.
The registry also indicated that 35 individuals — or 3.5 percent — developed melanoma.
STATEMENT OF ART: "Our guiding principle was that design is neither an intellectual nor a material affair, but simply an integral part of the stuff of life, necessary for everyone in a civilized society.", Walter Gropius.The MTA protects the respective rights of the institutions both giving and receiving the tissue.Both the institutions giving and receiving the tissue need a MTA and approval of the IRB.“If someone from another planet were looking at us, they would wonder why we are trying to create all the obstacles possible.” In fact, it took several years to go through this process at the University of Pittsburgh, which required a Material Transfer Agreement (MTA) and approval from the Institutional Review Board (IRB).The IRB is an ethics committee supervising the project to ensure that what Reyes is planning to do does not infringe into an ethical issue for the patient.